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Ovary Transplants: Are They Possible?

By: Kathryn Senior PhD - Updated: 3 Dec 2017 | comments*Discuss
 
Ovary Ovarian Transplant Premature

Yes, ovary transplants are now possible but the whole issue of whether they are a good idea was highlighted in the autumn of 2008 when a 38-year old woman became the first ovary transplant recipient to give birth to a baby. This sparked off several articles online and in newspapers claiming that this was women at their most selfish, that the new technique would allow women in their twenties to have one of their ovaries removed and frozen, to be transplanted later when their whims and careers dictated that they were ready for motherhood.

Why Women Would Need an Ovary Transplant

But is any of this true? As with many sensationalist reports, not really. It is true that it could become possible for a woman to have one ovary removed and frozen to be transplanted later but there are much more serious reasons why this would be necessary. Many women go through the menopause early – the woman who gave birth last year had suffered premature menopause at the age of 15. She had been completely infertile since then. Her twin, who already had two children, donated her sister one of her ovaries and the delicate operation was a success. She conceived the child she had longed for, for 20 years, just a year later.

Many other women lose their ovaries after radiation treatment that saves them from cancer. Others have kidney transplants or other organ transplants and the immunosuppressive therapy destroys the function of their ovaries. In total, more than 100 000 women are destined to be infertile because of ovary problems. If women were able to have an ovary removed before treatment, this would restore their fertility after treatment, allowing them to have a family.

What Does an Ovary Transplant Involve?

The operation is still quite experimental and is very specialised. In the few operations that have been done, the transplant has been between identical twins, which limits the problems of rejection. For a woman to donate an ovary to an unrelated women, they would need to be closely matched, as happens with other organ transplants.

The ovary is removed by keyhole surgery, so the recovery time for the donor is fairly quick. The ovary, which looks a bit like a walnut is then implanted using a more open surgery technique in which the tiny blood vessels are reconnected so that the transplanted ovary gets an adequate oxygen supply. This vascular part of the operation is the most delicate and takes the longest.

When the transplant is completed, it takes a few months for the ovary to start functioning normally but in the twins studied so far, hormone production seems to reach normal levels within about 5 months. The twin who gave birth last year found that her periods returned for the first time in 22 years and her osteoporosis showed signs of improvement, once her hormone levels stabilised.

Future Possibilities for Ovarian Transplant

The technique is still very much in its early days but could become more routine in the future as it would help so many women. The vascular surgery needs to be done by a very experienced surgeon, as the vessels that need to be reconnected are, in some cases, only a fraction of a millimetre in diameter. It is also possible to transplant strips of ovarian tissue and several women who have received this type of transplant have become pregnant successfully.

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[Add a Comment]
I am a 54 year old women who went through an early menopause. Since then I have developed all sorts of issues which I KNOW is caused by lack of estrogen, but all the so called medical professionals I have consult d disagree or have no response. Would, could a ovarian transplantbe used simply to reinstate estrogen into a woman body.m Please result.
June - 3-Dec-17 @ 3:45 PM
I have pcos with it cure it if I have this done
Kittycar1827 - 13-Oct-17 @ 5:37 AM
We are from India and my wife got pregnant through IVF treatment, now she is in her 17th week of pregnancy. We have already done NIPT and we are happy that the result was negative. Now we would like to take noninvasive prenatal paternity test. It is for our mental peace we are going for this test. However, we were told by a leading DNA lab in Delhi that due to some technical reasons noninvasive prenatal paternity test cannot be done in the case of IVF pregnancies. They say that DNA SNP technology gives result with 99.9% certainty only in the case of natural pregnancies. We would like to know that is there any advanced technology available that is as good in IVF pregnancies as in normal pregnancies. We are very confused, please advise us. Thank you. Regards K. Thiru
Worried Couple - 23-Aug-17 @ 11:08 AM
Janaka - Your Question:
Hi everyone,My wife 28 years old, her both ovaries removed due to cyst after that she is facing lot's lot's of problem like sleeping problem, burning sensation in hand feet crying, too much thing about family, I will die ect, would like to know is thiese are common problem women face after removing ovaries, what can we done to make her feel better, kindly help us

Our Response:
It may be partly depression and partly due to hormonal changes in her body. She really needs to go back to her GP and ask for help with this. If any of our readers has any experience of this we'd love to hear if you can offer anything that might be of help.
FertilityExpert - 9-Aug-17 @ 10:53 AM
Hi everyone, My wife 28 years old, her both ovaries removed due to cyst after that she is facing lot's lot's of problem like sleeping problem, burning sensation in hand feet crying, too much thing about family, I will die ect, would like to know is thiese are common problem women face after removing ovaries, what can we done to make her feel better, kindly help us
Janaka - 7-Aug-17 @ 4:37 PM
I'm 42 years old , and I'm on HRT tablets because I have high hormones levels (FSH, LH) post menopausal, can I do ovary transplant, how, how much does it cost ? How can I contact you.
Z - 5-Feb-17 @ 8:58 PM
I'm 38 years old , and I'm on HRT tablets because I have high hormones levels (FSH, LH) post menopausal, can I do ovary transplant, how, how much does it cost ? How can I contact you.
Amal - 30-Jan-17 @ 10:45 PM
Hi, One of my friend is suffering from PCO ( poly cystic ovaries) and as I understand there is very less chance to get pregnant and live normal life. So can we perform ovaries or uterus transplant from stranger to overcome the PCO? And can she get rid off PCO disease n it's symptoms after transplant? Can she conceive after transplant? I request you to please answer my queries.
Ashish - 10-Dec-16 @ 9:40 AM
Barb - Your Question:
Can you get an ovary transplant after having a complete hysterectomy ? Can it be from your daughter instead of a sister ? Or can it be from a stranger ? These are questions I would like to know ?

Our Response:
Sorry we can't answer this kind of question, you'd be better talking to your GP.
FertilityExpert - 22-Nov-16 @ 11:40 AM
Can you get an ovary transplant after having a complete hysterectomy ?Can it be from your daughter instead of a sister ? Or can it be from a stranger ? These are questions I would like to know ?
Barb - 21-Nov-16 @ 4:37 PM
Can a mother 41 yrs donate her one or both overies to her 16 yrs old daughter ?
Shailesh periwal - 8-Oct-16 @ 10:23 AM
Can mother of 42 yrs donate her overy to her 1u yrs old daughter ; who by birth does not have overy ??
Shailesh periwal - 8-Oct-16 @ 10:21 AM
I have read about the transplant of the ovarian. is there no way that one can pay every month for the procedure so long. the procedure is very expensive and I can't afford it. I am from Namibia and I so desperately want another baby I have only 1 daughter and the doctors remove my ovary due to cysts
Cleo - 26-Jul-16 @ 8:52 AM
@Smithy. Your GP should be your first port of call.
FertilityExpert - 8-Jan-15 @ 10:44 AM
Where do you go to enquire about having your sister donate an ovary tissue ?
Smithy - 6-Jan-15 @ 12:11 PM
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